Cardiac valve calcification and risk of cardiovascular or all-cause mortality in dialysis patients: a meta-analysis
نویسندگان
چکیده
BACKGROUND Vascular calcification is a risk factor for the pathogenesis of cardiovascular disease and mortality in dialysis patients. Nevertheless, the association between cardiac valve calcification (CVC) and the outcome of dialysis is still illusive. The purpose of this meta-analysis is to evaluate the association between theCVC and cardiovascular or all-cause mortality in dialysis patients. METHODS Literatures involving the baseline CVC and cardiovascular or all-cause mortality in dialysis patients were searchedfrom the PubMed, Embase, as well as two Chinese databases (i.e. Wanfang and CNKI databases). Articles published before November 2016were eligible to the study. RESULTS Ten studies involving 2686 participants were included. CVC was correlated with increased risk of cardiovascular mortality (hazard risk [HR]: 2.81; 95% confidence intervals [CI]: 1.92-4.10) and all-cause mortality (HR: 1.73; 95% CI: 1.42-2.11). Subgroup analysis showed an excess risk of all-cause mortality (HR: 1.35; 95% CI: 1.02-1.79) among patients with one CVC, and increased risk of all-cause mortality in patients with two CVCs (HR 2.15; 95% CI 1.57-2.94). CONCLUSIONS CVC is correlated with higher cardiovascular and all-cause mortality risk in dialysis patients. Regular follow-up monitoring of CVC may be helpful for risk stratification of patients underwent dialysis.
منابع مشابه
Author’s response to reviews Title: Cardiac valve calcification and risk of cardiovascular or all-cause mortality in dialysis patients: A meta-analysis Authors:
Title: Cardiac valve calcification and risk of cardiovascular or all-cause mortality in dialysis patients: A meta-analysis Authors: Zhe Wang ([email protected]) Aili Jiang ([email protected]) Fang Wei ([email protected]) Haiyan Chen ([email protected]) Version: 3 Date: 29 May 2017 Author’s response to reviews: Mohan Palla (Reviewer 1): The weighted outcome measure P-value should be repor...
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